Observation of Human Retinal Remodeling in Octogenarians with a Resveratrol Based Nutritional Supplement (PDF)

These notable cases support our original publication as well as work presented in India and subsequently published [1,2]. Resveratrol (RV) was discovered in the US in the 1940s, and later found to be an anti-hyperlipidemic medicinal component of grapes and red wine, also extracted from dried roots of the common weed Polygonum cuspidatum. In the modern era, RV has been characterized as a promiscuous, gene regulating, small molecular weight, polyphenol phytoalexin demonstrating broad-spectrum cell receptor and microRNA activity. It protects cells against mitochondrial DNA mutations, has “anti-aging” SIRTUIN activation /deactivation properties, modulates inflammation and most recently mitigated the earliest atherosclerotic marker (loss of flow-mediated dilatation) in a Japanese human clinical trial [3]. The second international conference on the biology of RV [4] and two major literature reviews have broad medical interest [5,6]. There are nearly 3500 papers in PubMed concerning some aspect of RV’s ability to inhibit carcinogenesis at all three stages of initiation, promotion, and progression.

Articles from Nutrients are provided here courtesy of Multidisciplinary Digital Publishing Institute (MDPI)

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