Health News UK

An animal study conducted by Kyowa Hakko has shown that the company’s patented L-citrulline/L-arginine ingredient is effective in boosting plasma L-arginine levels enhancing nitric oxide bioavailability post supplementation.

By Hank Schultz -

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A combination of l-arginine with folic acid, vitamins B6 and B12 may improve vascular function and help reduce blood pressure, says a new study from Germany.

By Stephen Daniells -

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While other vitamins and nutrients​ have hit the headlines for their positive effect on health in recent years, it seems that the importance of vitamin K2 as a modulator or controller​ of many other processes has been too often overlooked.

In this expert forum, NutraIngredients brings together world-leading experts​ to discuss the emerging and established science behind the role of vitamin K2 in health​ - and ask why it has been overlooked for so long.


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Low vitamin C levels appear to impair the gut-liver axis' role in vitamin E transfer and bioavailability that is crucial in preventing inflammation, as a review reveals its findings in metabolic syndrome (MetS) patients.

By Will Chu -

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Cognitive decline is fast becoming the biggest concern​ of the 65+ population. A population which is set to reach 1.1 billion​ by 2030*.

  • 80%​ of 60+ take supplements to help them age more healthily**
  • 72%​ of consumers seek improved memory from cognitive supplements*
  • 59%​ of consumers want to maintain a healthy cognitive function using cognitive supplements*

Studies show resveratrol:

  • Increases blood flow to the brain
  • Improves memory
  • Increases mood perception

Could resveratrol be the ingredient consumers are looking for? Download our White Paper and dive into the science.

**NBJ 2015​

Many studies have linked polyphenols—chemical compounds found in everything from chocolate to olives to berries—to reduced cardiovascular disease risk. French researchers took a closer look at how different types of polyphenols relate to this risk.

By Adi Menayang -

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Nitric oxide signaling alterations in outflow facility and retinal blood flow autoregulation are implicated in primary open-angle glaucoma (POAG). Nitric oxide donation has emerged as a POAG therapeutic target. An exogenous source of nitric oxide is dietary nitrates.

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NO is an important biological marker in the activity of the inflammatory process and endothelial dysfunction in bronchopulmonary diseases. Endothelial dysfunction appears as a primary element for vessel wall lesion that causes formation of the cardiovascular effects in asthma.

Cardiovascular effects are considered as system displays of various diseases, among which endothelial dysfunction appears as the primary element of a vessel wall lesion. Studying NO metabolites and L-arginine content plays an important role for required correction in the respiratory system endothelium.

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L-Arginine, the amino acid substrate for nitric oxide synthase, has been tested as a therapeutic intervention in a variety of chronic diseases and is commonly used as a nutritional supplement. In this study, we hypothesized that a subset of moderate to severe persistent asthma patients would benefit from supplementation with L-arginine by transiently increasing nitric oxide levels, resulting in bronchodilation and a reduction in inflammation. The pilot study consisted of a 3 month randomized, double-blind, placebocontrolled trial of L-arginine (0.05 g/kg twice daily) in patients with moderate to severe asthma. We measured spirometry, exhaled breath nitric oxide, serum arginine metabolites, questionnaire scores, daily medication use and PEFR with the primary endpoint being the number of minor exacerbations at three months. Interim analysis of the 20 subjects showed no difference in the number of exacerbations, exhaled nitric oxide levels or lung function between groups, though participants in the L-arginine group had higher serum L-arginine at day 60 (2.0 ± 0.6 × 10−3 vs. 1.1 ± 0.2 × 10−3 μmol/L, p

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Recent studies suggest that a nitric oxide (NO) deficiency and elevated arginase activity may play a role in the pathogenesis of asthma. Although much attention has been directed toward measurements of exhaled NO in asthma, no studies to date have evaluated levels of plasma arginase or arginine, the substrate for NO production, in patients with asthma. This study, therefore, measured amino acid levels, arginase activity, and nitric oxide metabolites in the blood of patients with asthma, as well as NO in exhaled breath. Although levels of virtually all amino acids were reduced, patients with asthma exhibited a striking reduction in plasma arginine levels compared with normal control subjects without asthma and serum arginase activity was elevated. High arginase activity in patients with asthma may contribute to low circulating arginine levels, thereby limiting arginine bioavailability and creating a NO deficiency that induces hyperreactive airways. Addressing the alterations in arginine metabolism may result in new strategies for treatment of asthma.

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